A NOVEL PD-L1-TARGETED SHARK VNAR SINGLE-DOMAIN-BASED CAR-T CELL STRATEGY FOR TREATING BREAST CANCER AND LIVER CANCER

A novel PD-L1-targeted shark VNAR single-domain-based CAR-T cell strategy for treating breast cancer and liver cancer

Chimeric antigen receptor (CAR)-T cell therapy shows excellent potency against hematological malignancies, but it remains challenging to treat solid tumors, mainly because of a lack of appropriate antigenic targets and an immunosuppressive tumor microenvironment (TME).The checkpoint molecule programmed death-ligand 1 (PD-L1) is widely overexpressed

read more


Animal Bites in ENT

Introduction: Animal bites can range Mobile Accessories from abrasions to laceration injury and are notorious for causing infectious diseases like rabies.Four such animal bite cases presented to ENT emergency, two of them assaulted by the Royal Bengal Tiger and the remaining two were bitten by their pet dogs.The management protocol has been discuss

read more